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Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

Abstract:

Increased expression of the regulatory subunit of HIFs (HIF-1α or HIF-2α) is associated with metabolic adaptation, angiogenesis, and tumor progression. Understanding how HIFs are regulated is of intense interest. Intriguingly, the molecular mechanisms that link mitochondrial function with the HIF-regulated response to hypoxia remain to be unraveled. Here we describe what we believe to be novel functions of the human gene CHCHD4 in this context. We found that CHCHD4 encodes 2 alternatively spl...

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Publisher copy:
10.1172/JCI58780

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Journal:
Journal of Clinical Investigation
Volume:
122
Issue:
2
Pages:
600-611
Publication date:
2012-02-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:eaa3a502-3879-4554-a33f-2c61c0436cba
Source identifiers:
343035
Local pid:
pubs:343035
Language:
English

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