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Journal article

A novel mixing device for the reproducible generation of nonviral gene therapy formulations.

Abstract:

Nonviral gene therapy utilizing plasmid DNA (pDNA) complexed with cationic lipids (lipoplexes) or cationic polymers (polyplexes) has demonstrated considerable potential for the treatment of a variety of diseases. However, progress toward clinical application is often delayed by the lack of reliable and scalable mixing of components sufficient to guarantee consistent performance in vivo. Attempts to improve and standardize mixing have been limited by the sensitivity of pDNA to shear-related de...

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Publication status:
Published

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Publisher copy:
10.2144/000113498

Authors


Davies, LA More by this author
Nunez-Alonso, GA More by this author
Scheule, RK More by this author
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Journal:
BioTechniques
Volume:
49
Issue:
3
Pages:
666-668
Publication date:
2010-09-05
DOI:
EISSN:
1940-9818
ISSN:
0736-6205
URN:
uuid:eaa04b3b-3073-4be2-90d6-f48a0f26b0b2
Source identifiers:
246604
Local pid:
pubs:246604

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