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JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery.

Abstract:

The c-Jun N-terminal kinase (JNK) signaling pathway plays a critical role in mediating apoptosis in the developing and mature organism. The JNK signaling pathway is thought to induce apoptosis via transcription-dependent and transcription-independent mechanisms that remain to be elucidated. In this study, we report a novel mechanism by which the JNK signaling pathway directly activates a component of the cell death machinery. We have found that JNK catalyzes the phosphorylation of the BH3-onl...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m206113200

Authors


Journal:
The Journal of biological chemistry
Volume:
277
Issue:
43
Pages:
40944-40949
Publication date:
2002-10-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:ea99c990-5e9d-4add-80cb-cd86ecee8bb8
Source identifiers:
248018
Local pid:
pubs:248018

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