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Periodic courses of human 1-34 parathyroid peptide alternating with calcitriol paradoxically reduce bone remodelling in spinal osteoporosis.

Abstract:

In an attempt to achieve an anabolic response in both axial and peripheral bone, we treated twelve patients with osteoporosis using human 1-34 parathyroid peptide given discontinuously. The peptide was given as seven daily subcutaneous injections followed by 21 days' treatment with 0.25 mg calcitriol orally. This regime was repeated cyclically for at least sixteen cycles, of which the first four were at a lower dose of hPTH 1-34 than used subsequently. The results of treatment were monitored ...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Edouard, C More by this author
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Journal:
European journal of clinical investigation
Volume:
17
Issue:
5
Pages:
421-428
Publication date:
1987-10-05
DOI:
EISSN:
1365-2362
ISSN:
0014-2972
URN:
uuid:ea965be0-c26f-4799-ac57-f20e9e7dfbd9
Source identifiers:
473680
Local pid:
pubs:473680

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