Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis.
OBJECTIVE: While the hallmark of amyotrophic lateral sclerosis (ALS) is corticospinal tract in combination with lower motor neuron degeneration, the clinical involvement of both compartments is characteristically variable and the site of onset debated. We sought to establish whether there is a consistent signature of cerebral white matter abnormalities in heterogeneous ALS cases. METHODS: In this observational study, diffusion tensor imaging was applied in a whole-brain analysis of 24 heterog...Expand abstract
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