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RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II.

Abstract:

Non-canonical pathways of osteoclastogenesis have been described in which several cytokines are able to substitute for RANKL. These cytokines are few in number and their role(s) in pathological bone resorption has not been ascertained. We have identified five additional cytokines, APRIL, BAFF, NGF, IGF I and IGF II, that can induce RANKL-independent osteoclastogenesis. All five cytokines induced both osteoclast differentiation and activation with respect to the formation of significant number...

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Publisher copy:
10.1016/j.bone.2010.12.023

Authors


Hemingway, F More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Bone
Volume:
48
Issue:
4
Pages:
938-944
Publication date:
2011-04-01
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
URN:
uuid:ea8b9e32-4a58-4fe4-8569-26da04e99498
Source identifiers:
133233
Local pid:
pubs:133233

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