RANKL-independent human osteoclast formation with APRIL, BAFF, NGF, IGF I and IGF II.
Non-canonical pathways of osteoclastogenesis have been described in which several cytokines are able to substitute for RANKL. These cytokines are few in number and their role(s) in pathological bone resorption has not been ascertained. We have identified five additional cytokines, APRIL, BAFF, NGF, IGF I and IGF II, that can induce RANKL-independent osteoclastogenesis. All five cytokines induced both osteoclast differentiation and activation with respect to the formation of significant number...Expand abstract
- Publisher copy:
- Copyright date:
- PubMed ID: 21193069
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record