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HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1.

Abstract:

Recent studies provide compelling evidence that HIV-1 entry in cell lines and lymphocytes proceeds by endocytosis, but these studies are still lacking in macrophages, an important natural target cell for HIV-1. Macrophages exhibit continual and extensive endocytic activity as part of their natural functions, so we investigated the uptake pathways involved in productive HIV-1 entry. We find that caveolae are not utilised by HIV-1, because the main structural proteins, caveolin-1 and 2 are abse...

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Publication status:
Published

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Publisher copy:
10.1016/j.virol.2010.10.018

Authors


Carter, GC More by this author
Bernstone, L More by this author
Baskaran, D More by this author
Journal:
Virology
Volume:
409
Issue:
2
Pages:
234-250
Publication date:
2011-01-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:ea8afdc8-c47a-4120-846e-e2643e4c1b48
Source identifiers:
110168
Local pid:
pubs:110168

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