Expression and functional role of CD23 on T cells.

Journal article

We have found that approximately 10%-15% of tonsil, but not peripheral blood, T cells express the CD23 antigen following activation with 12-O-tetradecanoylphorbol 13-acetate (TPA), phytohemagglutinin (PHA) or recombinant interleukin 4. The proliferative response of tonsil T cells is significantly increased when CD23 monoclonal antibodies (mAb) are present in the cultures. In contrast, no such proliferative augmentation is seen when peripheral blood T cells are cultured in this way. Supernatan...

Expand abstract

Authors: Armitage, R; Goff, L; Beverley, P

• Journal: European journal of immunology
• Volume: 19
• Issue: 1
• Pages: 31-35
• Publication date: 1989-01-01
• DOI: 10.1002/eji.1830190106
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Phytohemagglutinins; Adjuvants, Immunologic; Antibodies, Monoclonal; Receptors, Fc; Humans; T-Lymphocytes; Receptors, IgE; Lymphocyte Activation; Palatine Tonsil; Antigens, Differentiation, B-Lymphocyte; Tetradecanoylphorbol Acetate; Solubility