Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

Journal article

Lipid transfer proteins, such as molecules of the saposin family, facilitate extraction of lipids from biological membranes for their loading onto CD1d molecules. Although it has been shown that prosaposin-deficient mice fail to positively select invariant natural killer T (iNKT) cells, it remains unclear whether saposins can facilitate loading of endogenous iNKT cell agonists in the periphery during inflammatory responses. In addition, it is unclear whether saposins, in addition to loading, ...

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Authors: Salio, M; Ghadbane, H; Dushek, O; Shepherd, D; Cypen, J

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 110
• Issue: 49
• Pages: E4753-E4761
• Publication date: 2013-12-01
• DOI: 10.1073/pnas.1310050110
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Humans; Immunoprecipitation; Saposins; Scintillation Counting; Enzyme-Linked Immunosorbent Assay; Bacteria; Immunity, Innate; Natural Killer T-Cells; HEK293 Cells; Antigen-Presenting Cells; Antigens, CD1d; Lipid Metabolism