Journal article
Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.
- Abstract:
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BACKGROUND: Heart failure is associated with deranged cardiac energy metabolism, including reductions of creatine and phosphocreatine. Interventions that increase myocardial high-energy phosphate stores have been proposed as a strategy for treatment of heart failure. Previously, it has not been possible to increase myocardial creatine and phosphocreatine concentrations to supranormal levels because they are subject to tight regulation by the sarcolemmal creatine transporter (CrT). METHODS AND...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/circulationaha.105.572990
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Bibliographic Details
- Journal:
- Circulation
- Volume:
- 112
- Issue:
- 20
- Pages:
- 3131-3139
- Publication date:
- 2005-11-01
- DOI:
- EISSN:
-
1524-4539
- ISSN:
-
0009-7322
- Source identifiers:
-
104223
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:104223
- UUID:
-
uuid:ea731ca2-8ace-404d-ba4e-242906097bf4
- Local pid:
- pubs:104223
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2005
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