- Abstract:
-
BACKGROUND: Heart failure is associated with deranged cardiac energy metabolism, including reductions of creatine and phosphocreatine. Interventions that increase myocardial high-energy phosphate stores have been proposed as a strategy for treatment of heart failure. Previously, it has not been possible to increase myocardial creatine and phosphocreatine concentrations to supranormal levels because they are subject to tight regulation by the sarcolemmal creatine transporter (CrT). METHODS AND...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1161/circulationaha.105.572990
-
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- Journal:
- Circulation
- Volume:
- 112
- Issue:
- 20
- Pages:
- 3131-3139
- Publication date:
- 2005-11-05
- DOI:
- EISSN:
-
1524-4539
- ISSN:
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0009-7322
- URN:
-
uuid:ea731ca2-8ace-404d-ba4e-242906097bf4
- Source identifiers:
-
104223
- Local pid:
- pubs:104223
- Copyright date:
- 2005
Journal article
Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice.
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