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HLA-D subregion expression by thyroid epithelium in autoimmune thyroid diseases and induced in vitro.

Abstract:

Human thyroid epithelial cells (thyrocytes) express HLA Class II molecules in autoimmune thyroid diseases (ATD). Normal thyrocytes do not express Class II, but can be induced to do so by culture with interferon-gamma (gamma-IFN). We have examined HLA-D subregion expression in sections and monolayers of thyroid by indirect immunofluorescence using appropriate monoclonal antibodies. The results indicate that, in ATD, the incidence and intensity of Class II subregion expression by thyrocytes var...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Clinical and experimental immunology
Volume:
69
Issue:
3
Pages:
532-542
Publication date:
1987-09-05
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:ea6b4c63-e216-49d1-9cd5-97bea6d27f54
Source identifiers:
481797
Local pid:
pubs:481797

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