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Definition of the unique human extraocular muscle allotype by expression profiling.

Abstract:

The extraocular muscles (EOMs) are a unique group of specialized muscles that are anatomically and physiologically distinct from other skeletal muscles. Perhaps the most striking characteristic of the EOMs is their differential sensitivity to disease. EOMs are spared in Duchenne's muscular dystrophy (DMD) despite widespread involvement of other skeletal muscles. Conversely, they are early and prominent targets in myasthenia gravis and mitochondrial myopathies. It is unclear how EOMs achieve s...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Physiological genomics
Volume:
22
Issue:
3
Pages:
283-291
Publication date:
2005-08-05
DOI:
EISSN:
1531-2267
ISSN:
1094-8341
URN:
uuid:ea6b0dad-1ffd-40b8-be7d-8d5756e14f78
Source identifiers:
372298
Local pid:
pubs:372298

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