Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol.

Journal article

While ubiquitous, pharmacological manipulation of consciousness remains poorly defined and incompletely understood (Prys-Roberts, 1987). This retards anesthetic drug development, confounds interpretation of animal studies conducted under anesthesia, and limits the sensitivity of clinical monitors of cerebral function to intact perception. Animal and human studies propose a functional "switch" at the level of the thalamus, with inhibition of thalamo-cortical transmission characterizing loss of...

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Authors: Mhuircheartaigh, R; Rosenorn-Lanng, D; Wise, R; Jbabdi, S; Rogers, R

• Publication status: Published
• Journal: Journal of neuroscience : the official journal of the Society for Neuroscience
• Volume: 30
• Issue: 27
• Pages: 9095-9102
• Publication date: 2010-07-01
• DOI: 10.1523/jneurosci.5516-09.2010
• EISSN: 1529-2401
• ISSN: 0270-6474
• Language: English
• Keywords: Acoustic Stimulation; Humans; Brain Mapping; Pain; Young Adult; Physical Stimulation; Adult; Brain; Psychophysics; Male; Oxygen; Neural Pathways; Consciousness; Hypnotics and Sedatives; Image Processing, Computer-Assisted; Time Factors; Propofol; Female; Analysis of Variance; Magnetic Resonance Imaging; Neuropsychological Tests