HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy.

Conference item

The risk of disease associated with persistent virus infections such as HIV-I, hepatitis B and C, and human T-lymphotropic virus-I (HTLV-I) is strongly determined by the virus load. However, it is not known whether a persistent class I HLA-restricted antiviral cytotoxic T lymphocyte (CTL) response reduces viral load and is therefore beneficial or causes tissue damage and contributes to disease pathogenesis. HTLV-I-associated myelopathy (HAM/TSP) patients have a high virus load compared with a...

Expand abstract

Authors: Jeffery, K; Usuku, K; Hall, SE; Matsumoto, W; Taylor, G

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 96
• Issue: 7
• Pages: 3848-3853
• Publication date: 1999-03-01
• Event title: National-Academy-of-Sciences Colloquium on Geology, Mineralogy, and Human Welfare
• DOI: 10.1073/pnas.96.7.3848
• EISSN: 1091-6490
• ISSN: 0027-8424
• Keywords: Humans; Viral Load; Genetic Predisposition to Disease; Human T-lymphotropic virus 1; Genes, MHC Class I; Alleles; Risk Factors; HLA-B Antigens; HLA-DRB1 Chains; HTLV-I Infections; Paraparesis, Tropical Spastic; Histocompatibility Testing; HLA-DR Antigens; HLA-A Antigens; Genes, MHC Class II