- Abstract:
-
Dominant mutations in the ubiquitous enzyme glycyl-tRNA synthetase (GlyRS), including S581L, lead to motor nerve degeneration. We have determined crystal structures of wildtype and S581L-mutant human GlyRS. The S581L mutation is approximately 50A from the active site, and yet gives reduced aminoacylation activity. The overall structures of wildtype and S581L-GlyRS, including the active site, are very similar. However, residues 567-575 of the anticodon-binding domain shift position and in turn...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.febslet.2007.05.046
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- Journal:
- FEBS letters
- Volume:
- 581
- Issue:
- 16
- Pages:
- 2959-2964
- Publication date:
- 2007-06-05
- DOI:
- EISSN:
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1873-3468
- ISSN:
-
0014-5793
- URN:
-
uuid:ea618814-ccae-43bc-80d2-9bd8d5d35004
- Source identifiers:
-
72646
- Local pid:
- pubs:72646
- Copyright date:
- 2007
Journal article
Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy.
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