Journal article icon

Journal article

Spatial learning depends on both the addition and removal of new hippocampal neurons

Abstract:

The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory a...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pbio.0050214

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Expand authors...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
5
Issue:
8
Pages:
e214
Publication date:
2007-08-07
Acceptance date:
2007-06-11
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Source identifiers:
329235
Language:
English
Keywords:
Pubs id:
pubs:329235
UUID:
uuid:ea5cd169-c17c-49d0-aef9-830a02c41a10
Local pid:
pubs:329235
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP