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Spatial learning depends on both the addition and removal of new hippocampal neurons

Abstract:

The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pbio.0050214

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
5
Issue:
8
Pages:
e214
Publication date:
2007-08-07
Acceptance date:
2007-06-11
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
URN:
uuid:ea5cd169-c17c-49d0-aef9-830a02c41a10
Source identifiers:
329235
Local pid:
pubs:329235

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