- Abstract:
-
BACKGROUND: The authors reported a mutation, P1158S, of the human skeletal muscle sodium channel gene (SCN4A) in a family with cold-induced hypokalemic periodic paralysis (hypoKPP) and myotonia. OBJECTIVE: To identify mechanisms of temperature dependency in this channelopathy. METHODS: Using the amphotericin B perforated patch clamp method, sodium currents were recorded at 22 and 32 degrees C from the wild-type (WT) and P1158S mutant SCN4A expressed in tsA201 cells. Computer simulation was pe...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1212/01.wnl.0000086820.54065.a0
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- Volume:
- 61
- Issue:
- 7
- Pages:
- 914-918
- Publication date:
- 2003-10-05
- DOI:
- EISSN:
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1526-632X
- ISSN:
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0028-3878
- URN:
-
uuid:ea5a5a87-2ce0-4bde-bc30-9441b3ab56fb
- Source identifiers:
-
57222
- Local pid:
- pubs:57222
- Copyright date:
- 2003
Conference
Cold induces shifts of voltage dependence in mutant SCN4A, causing hypokalemic periodic paralysis.
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