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Cold induces shifts of voltage dependence in mutant SCN4A, causing hypokalemic periodic paralysis.

Abstract:

BACKGROUND: The authors reported a mutation, P1158S, of the human skeletal muscle sodium channel gene (SCN4A) in a family with cold-induced hypokalemic periodic paralysis (hypoKPP) and myotonia. OBJECTIVE: To identify mechanisms of temperature dependency in this channelopathy. METHODS: Using the amphotericin B perforated patch clamp method, sodium currents were recorded at 22 and 32 degrees C from the wild-type (WT) and P1158S mutant SCN4A expressed in tsA201 cells. Computer simulation was pe...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Volume:
61
Issue:
7
Pages:
914-918
Publication date:
2003-10-05
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
URN:
uuid:ea5a5a87-2ce0-4bde-bc30-9441b3ab56fb
Source identifiers:
57222
Local pid:
pubs:57222

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