Journal article
Stress, inflammation and hippocampal subfields in depression: A 7 tesla MRI study
- Abstract:
- Experiencing stressful events throughout one's life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation such as Interleukin (IL-6) and C-reactive protein (CRP), have been linked to both early life stress and MDD. We aimed to explore the biological stress signatures of early stress and MDD on hippocampal sub regional volumes using 7 Tesla MRI imaging. A cohort of 71 MDD patients was compared against 46 age and sex-matched healthy volunteers. MDD subjects had higher averages of IL-6 and CRP levels. These differences were significant for IL-6 levels and trended for CRP. There were no significant group differences in any of the hippocampal subfields or global hippocampal volumes; further, there were no hippocampal subfield differences between MDD subjects with high levels of our biological stress measures and MDDs with normal levels.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 857.9KB, Terms of use)
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- Publisher copy:
- 10.1038/s41398-020-0759-0
Authors
- Publisher:
- Springer Nature
- Journal:
- Translational Psychiatry More from this journal
- Volume:
- 10
- Issue:
- 1
- Article number:
- 78
- Publication date:
- 2020-02-25
- Acceptance date:
- 2020-01-02
- DOI:
- EISSN:
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2158-3188
- ISSN:
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2158-3188
- Pmid:
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32098947
- Language:
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English
- Pubs id:
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1094604
- Local pid:
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pubs:1094604
- Deposit date:
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2020-06-17
Terms of use
- Copyright holder:
- Tannous et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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