Leiomyoma of the bladder in a patient with von Recklinghausen's neurofibromatosis.

Journal article

Leiomyomas are an uncommon manifestation of neurofibromatosis type 1 (NF-1) and occur most often in the gastrointestinal tract. Here, they have a proclivity for the proximal small bowel and tend to be multiple. Urinary tract involvement by NF-1 is usually in the form of neurofibromas, and leiomyomas are exceptionally rare. This report describes a case of solitary leiomyoma occurring in a 49 year old woman with NF-1. The patient had symptoms related to a lower urinary tract infection and on examination was found to have a distended bladder. Imaging of the bladder showed a mass involving the posterior wall, neck, and trigone causing bilateral hydronephrosis. The mass was excised with part of the bladder. Microscopic examination revealed typical features of a leiomyoma and there was strong immunoreactivity for desmin and smooth muscle actin. Leiomyoma must be considered in the differential diagnosis of spindle cell neoplasms in patients with NF-1.

Authors: Däuth, T; Conradie, M; Chetty, R

• Publication status: Published
• Journal: Journal of clinical pathology
• Volume: 56
• Issue: 9
• Pages: 711-712
• Publication date: 2003-09-01
• DOI: 10.1136/jcp.56.9.711
• EISSN: 1472-4146
• ISSN: 0021-9746
• Language: English
• Keywords: Middle Aged; Leiomyoma; Humans; Urinary Bladder Neoplasms; Neurofibromatosis 1; Female