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Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials

Abstract:
Background A one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes. Methods Using individual patient data, we analysed the modifying effects of bodyweight (10 kg bands) and height (10 cm bands) on the effects of low doses (≤100 mg) and high... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/S0140-6736(18)31133-4

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Oxford college:
St Edmund Hall
Gaziano, JM More by this author
Belch, JFF More by this author
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Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet Journal website
Volume:
392
Issue:
10145
Pages:
387-399
Publication date:
2018-07-17
Acceptance date:
2018-05-15
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
Pubs id:
pubs:891486
URN:
uri:ea50dcbc-8206-4d34-92a5-25d8b6e2a604
UUID:
uuid:ea50dcbc-8206-4d34-92a5-25d8b6e2a604
Local pid:
pubs:891486

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