Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials

Journal article

Background A one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes. Methods Using individual patient data, we analysed the modifying effects of bodyweight (10 kg bands) and height (10 cm bands) on the effects of low doses (≤100 mg) and high... Expand abstract

Authors: Rothwell, P; Cook, N; Gaziano, J; Price, J; Belch, J

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Lancet
• Volume: 392
• Issue: 10145
• Pages: 387-399
• Publication date: 2018-07-17
• Acceptance date: 2018-05-15
• DOI: 10.1016/S0140-6736(18)31133-4
• EISSN: 1474-547X
• ISSN: 0140-6736
• Pmid: 30017552
• Language: English
• Keywords: stroke; male; aspirin; humans; body height; platelet aggregation inhibitors; proportional hazards models; age factors; colorectal neoplasms; aged; Kaplan-Meier estimate; female; cardiovascular diseases; risk factors; sex factors; body weight; death; sudden; randomized controlled trials as topic