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Journal article

Methods for specifying the target difference in a randomised controlled trial: the Difference ELicitation in TriAls (DELTA) systematic review.

Abstract:

BACKGROUND: Randomised controlled trials (RCTs) are widely accepted as the preferred study design for evaluating healthcare interventions. When the sample size is determined, a (target) difference is typically specified that the RCT is designed to detect. This provides reassurance that the study will be informative, i.e., should such a difference exist, it is likely to be detected with the required statistical precision. The aim of this review was to identify potential methods for specifying ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1001645

Authors


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Medical Research Council More from this funder
National Institute for Health Research More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
11
Issue:
5
Pages:
e1001645
Chapter number:
ARTN e1001645
Publication date:
2014-01-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:ea4df225-e5bb-4589-ac50-86d2ad35fee3
Source identifiers:
465180
Local pid:
pubs:465180

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