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Methods for specifying the target difference in a randomised controlled trial: the Difference ELicitation in TriAls (DELTA) systematic review.

Abstract:

BACKGROUND: Randomised controlled trials (RCTs) are widely accepted as the preferred study design for evaluating healthcare interventions. When the sample size is determined, a (target) difference is typically specified that the RCT is designed to detect. This provides reassurance that the study will be informative, i.e., should such a difference exist, it is likely to be detected with the required statistical precision. The aim of this review was to identify potential methods for specifying ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.1001645

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Publisher:
Public Library of Science
Journal:
PLoS medicine More from this journal
Volume:
11
Issue:
5
Pages:
e1001645
Publication date:
2014-01-01
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
Language:
English
Keywords:
Pubs id:
pubs:465180
UUID:
uuid:ea4df225-e5bb-4589-ac50-86d2ad35fee3
Local pid:
pubs:465180
Source identifiers:
465180
Deposit date:
2014-06-17

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