Journal article icon

Journal article

Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia.

Abstract:

The tumor suppressor p53 is a master sensor of stress. Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity and MDM2 SNP309 G/G in a cohort of 4029 individuals across Eastern Asia that suggests causative selection. Moreover, the two polymorphisms are not coselected. Haplotype-based selection analysis further suggests that this is a striking exampl...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.ajhg.2009.03.009

Authors


Expand authors...
Journal:
American journal of human genetics
Volume:
84
Issue:
4
Pages:
534-541
Publication date:
2009-04-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:ea4c13cd-5171-4cba-8b1d-2792c1e026c6
Source identifiers:
41143
Local pid:
pubs:41143

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP