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A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine.

Abstract:

Ketamine and (+)-N-allylnormetazocine ((+)-NANM) were found to generalize in a rat operant drug discrimination paradigm to the interoceptive stimulus induced by phencyclidine (PCP). Intraperitoneal administration of the non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, MK-801, and intracerebroventricular injection of the competitive antagonist, 2-DL-amino-7-phosphonoheptanoic acid (2-APH), also resulted in a dose-dependent generalisation to the PCP discriminative stimulu...

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Publication status:
Published

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Authors


Tricklebank, MD More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
European journal of pharmacology
Volume:
141
Issue:
3
Pages:
497-501
Publication date:
1987-09-05
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
URN:
uuid:ea4ad12a-e7d9-4330-9bab-60f24a9e798d
Source identifiers:
19499
Local pid:
pubs:19499

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