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HCV genotype-3a T cell immunity: specificity, function and impact of therapy.

Abstract:

BACKGROUND: Hepatitis C virus (HCV) genotype-3a infection is now the dominant strain in South Asia and the UK. Characteristic features include a favourable response to therapy; the reasons for this are unknown but may include distinct genotype-3a-specific T cell immunity. In contrast to genotype-1 infection, T cell immunity to this subtype is poorly defined. OBJECTIVES: The aims of the study were to (1) define the frequency, specificity and cross-reactivity of T cell immunity across the whole...

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Publication status:
Published

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Publisher copy:
10.1136/gutjnl-2011-300650

Authors


Humphreys, IS More by this author
von Delft, A More by this author
Hibbert, L More by this author
Collier, JD More by this author
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Journal:
Gut
Volume:
61
Issue:
11
Pages:
1589-1599
Publication date:
2012-11-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:ea4a956c-800a-4d68-b3b8-72c5cb26a31c
Source identifiers:
256188
Local pid:
pubs:256188

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