ASPP [corrected] and cancer.

Journal article

One of the most frequently mutated genes in human cancers, tumour suppressor p53 (TP53), can induce cell-cycle arrest and apoptosis. The apoptotic function of p53 is tightly linked to its tumour-suppression function and the efficacy of many cancer therapies depends on this. The identification of a new family of proteins, known as ASPPs (ankyrin-repeat-, SH3-domain- and proline-rich-region-containing proteins), has led to the discovery of a novel mechanism that selectively regulates the apoptotic function, but not the cell-cycle-arrest function, of p53, and gives an insight into how p53 responds to different stress signals. ASPPs might be new molecular targets for cancer therapy.

Authors: Trigiante, G; Lu, X

• Publication status: Published
• Journal: Nature reviews. Cancer
• Volume: 6
• Issue: 3
• Pages: 217-226
• Publication date: 2006-03-01
• DOI: 10.1038/nrc1818
• EISSN: 1474-1768
• ISSN: 1474-175X
• Language: English
• Keywords: Tumor Suppressor Protein p53; Neoplasms; Cell Cycle; Apoptosis; Humans