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The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic

Abstract:

Esophageal adenocarcinoma (EAC) is a poor-prognosis cancer type with rapidly rising incidence. Understanding of the genetic events driving EAC development is limited, and there are few molecular biomarkers for prognostication or therapeutics. Using a cohort of 551 genomically characterized EACs with matched RNA sequencing data, we discovered 77 EAC driver genes and 21 noncoding driver elements. We identified a mean of 4.4 driver events per tumor, which were derived more commonly from mutation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41588-018-0331-5

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ORCID:
0000-0002-0341-7878
Jammula, S More by this author
Contino, G More by this author
Killcoyne, S More by this author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
51
Issue:
3
Pages:
506-516
Publication date:
2019-02-04
Acceptance date:
2018-12-10
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:976358
URN:
uri:ea3ef701-706c-47d6-9991-e4a7d8c173a1
UUID:
uuid:ea3ef701-706c-47d6-9991-e4a7d8c173a1
Local pid:
pubs:976358

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