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Journal article

The carbomer-lecithin adjuvant adjuplex has potent immunoactivating properties and elicits protective adaptive immunity against influenza virus challenge in mice

Abstract:

The continued discovery and development of adjuvants for vaccine formulation are important to safely increase potency and/or reduce the antigen doses of existing vaccines and tailor the adaptive immune response to newly developed vaccines. Adjuplex is a novel adjuvant platform based on a purified lecithin and carbomer homopolymer. Here, we analyzed the adjuvant activity of Adjuplex in mice for the soluble hemagglutinin (HA) glycoprotein of influenza A virus. The titration of Adjuplex revealed...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/CVI.00736-14

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, WIMM
Role:
Author
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Advanced BioAdjuvants LLC More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Clinical and Vaccine Immunology Journal website
Volume:
22
Issue:
9
Pages:
1004-1012
Publication date:
2015-01-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:ea3cb285-4a82-47b2-b7bc-742555ef9f0f
Source identifiers:
531377
Local pid:
pubs:531377
Language:
English

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