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Enhanced CD8+ T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus.

Abstract:

Sterile immunity can be provided against the pre-erythrocytic stages of malaria by IFN-gamma-secreting CD8(+) T cells that recognize parasite-infected hepatocytes. In this study, we have investigated the use of attenuated fowlpox virus (FPV) strains as recombinant vaccine vectors for eliciting CD8(+) T cells against Plasmodium berghei. The gene encoding the P. berghei circumsporozoite (PbCS) protein was inserted into an FPV vaccine strain licensed for use in chickens, Webster's FPV, and the n...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.172.5.3094

Authors


Anderson, RJ More by this author
Hannan, CM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Laidlaw, SM More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
172
Issue:
5
Pages:
3094-3100
Publication date:
2004-03-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:ea3924d4-1efd-401e-9e62-285f791930fc
Source identifiers:
32633
Local pid:
pubs:32633

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