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Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity

Abstract:

Substantial protection can be provided against the pre-erythrocytic stages of malaria by vaccination first with an adenoviral and then with an modified vaccinia virus Ankara (MVA) poxviral vector encoding the same ME.TRAP transgene. We investigated whether the two vaccine components adenovirus (Ad) and MVA could be coinjected as a mixture to enhance protection against malaria. A single-shot mixture at specific ratios of Ad and MVA (AdMVA) enhanced CD8 ++ T cell-dependant protection of mice ag...

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Publisher copy:
10.1038/mt.2012.25

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Journal:
Molecular Therapy
Volume:
20
Issue:
8
Pages:
1633-1647
Publication date:
2012-08-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:ea36f5db-4269-4456-a950-31c3baeb7343
Source identifiers:
348832
Local pid:
pubs:348832
Language:
English

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