Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

Journal article

Age-related changes in DNA methylation have been implicated in cellular senescence and longevity, yet the causes and functional consequences of these variants remain unclear. To elucidate the role of age-related epigenetic changes in healthy ageing and potential longevity, we tested for association between whole-blood DNA methylation patterns in 172 female twins aged 32 to 80 with age and age-related phenotypes. Twin-based DNA methylation levels at 26,690 CpG-sites showed evidence for mean ge...

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Authors: Bell, J; Tsai, P; Yang, T; Pidsley, R; Nisbet, J

• Publication status: Published
• Journal: PLoS genetics
• Volume: 8
• Issue: 4
• Pages: e1002629
• Publication date: 2012-01-01
• DOI: 10.1371/journal.pgen.1002629
• EISSN: 1553-7404
• ISSN: 1553-7390
• Language: English
• Keywords: Female; Humans; Quantitative Trait Loci; Aging; Cell Aging; CpG Islands; Longevity; Epigenesis, Genetic; Gene-Environment Interaction; MuTHER Consortium; Middle Aged; Aged, 80 and over; Genome, Human; Genome-Wide Association Study; Genetic Association Studies; Aged; Twins, Monozygotic; DNA Methylation; Adult