PIP2 and PIP as determinants for ATP inhibition of KATP channels.

Journal article

Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels couple electrical activity to cellular metabolism through their inhibition by intracellular ATP. ATP inhibition of KATP channels varies among tissues and is affected by the metabolic and regulatory state of individual cells, suggesting involvement of endogenous factors. It is reported here that phosphatidylinositol-4, 5-bisphosphate (PIP2) and phosphatidylinositol-4-phosphate (PIP) controlled ATP inhibition of cloned KATP channe...

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Authors: Baukrowitz, T; Schulte, U; Oliver, D; Herlitze, S; Krauter, T

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 282
• Issue: 5391
• Pages: 1141-1144
• Publication date: 1998-11-01
• DOI: 10.1126/science.282.5391.1141
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Dose-Response Relationship, Drug; Adenosine Triphosphate; Potassium Channel Blockers; Oocytes; Phosphatidylinositols; Receptors, Purinergic P2Y2; Receptors, Drug; Phosphatidylinositol 4,5-Diphosphate; Mutation; ATP-Binding Cassette Transporters; Phosphatidylinositol Phosphates; Type C Phospholipases; Cloning, Molecular; Animals; Potassium Channels; Recombinant Fusion Proteins; Potassium Channels, Inwardly Rectifying; Diazoxide; Patch-Clamp Techniques; Xenopus laevis; Receptors, Purinergic P2