Soil-transmitted helminths and Mycobacterium tuberculosis frequently coincide geographically and it is hypothesized that gastrointestinal helminth infection may exacerbate tuberculosis (TB) disease by suppression of Th1 and Th17 responses. However, few studies have focused on latent TB infection (LTBI), which predominates globally. We performed a large observational study of healthy adults migrating from Nepal to the UK (n = 645). Individuals were screened for LTBI and gastrointestinal parasi...Expand abstract
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- Frontiers in Immunology Journal website
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© 2018 O'Shea, Fletcher, Muller, Tanner, Matsumiya, Bailey, Jones, Smith, Koh, Horsnell, Beeching, Dunbar, Wilson, Cunningham and McShane.
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Human hookworm infection enhances mycobacterial growth inhibition and associates with reduced risk of tuberculosis infection
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