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Human hookworm infection enhances mycobacterial growth inhibition and associates with reduced risk of tuberculosis infection

Abstract:

Soil-transmitted helminths and Mycobacterium tuberculosis frequently coincide geographically and it is hypothesized that gastrointestinal helminth infection may exacerbate tuberculosis (TB) disease by suppression of Th1 and Th17 responses. However, few studies have focused on latent TB infection (LTBI), which predominates globally. We performed a large observational study of healthy adults migrating from Nepal to the UK (n = 645). Individuals were screened for LTBI and gastrointestinal parasi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.3389/fimmu.2018.02893

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Jenner Institute
Role:
Author
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Publication date:
2018-12-14
Acceptance date:
2018-11-26
DOI:
EISSN:
1664-3224
Pubs id:
pubs:955378
URN:
uri:ea2a99ef-7960-451f-8271-ba4bd3a60139
UUID:
uuid:ea2a99ef-7960-451f-8271-ba4bd3a60139
Local pid:
pubs:955378
Paper number:
2893

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