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A "Long Indel" model for evolutionary sequence alignment.

Abstract:

We present a new probabilistic model of sequence evolution, allowing indels of arbitrary length, and give sequence alignment algorithms for our model. Previously implemented evolutionary models have allowed (at most) single-residue indels or have introduced artifacts such as the existence of indivisible "fragments." We compare our algorithm to these previous methods by applying it to the structural homology dataset HOMSTRAD, evaluating the accuracy of (1) alignments and (2) evolutionary time ...

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Publication status:
Published

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Publisher copy:
10.1093/molbev/msh043

Authors


Miklós, I More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Molecular biology and evolution
Volume:
21
Issue:
3
Pages:
529-540
Publication date:
2004-03-05
DOI:
EISSN:
1537-1719
ISSN:
0737-4038
URN:
uuid:ea1a6c7f-2ec9-4e20-af08-a2fd943a743a
Source identifiers:
68374
Local pid:
pubs:68374

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