A "Long Indel" model for evolutionary sequence alignment.

Journal article

We present a new probabilistic model of sequence evolution, allowing indels of arbitrary length, and give sequence alignment algorithms for our model. Previously implemented evolutionary models have allowed (at most) single-residue indels or have introduced artifacts such as the existence of indivisible "fragments." We compare our algorithm to these previous methods by applying it to the structural homology dataset HOMSTRAD, evaluating the accuracy of (1) alignments and (2) evolutionary time ...

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Authors: Miklós, I; Lunter, G; Holmes, I

• Publication status: Published
• Journal: Molecular biology and evolution
• Volume: 21
• Issue: 3
• Pages: 529-540
• Publication date: 2004-03-01
• DOI: 10.1093/molbev/msh043
• EISSN: 1537-1719
• ISSN: 0737-4038
• Language: English
• Keywords: Algorithms; Likelihood Functions; Sequence Alignment; Markov Chains; Evolution, Molecular