Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis.

Journal article

PURPOSE: We determined the role of factor inhibiting hypoxia-inducible factor-1 in prostate cancer specimens. MATERIALS AND METHODS: A tissue microarray of 152 prostate cancers was constructed and stained for factor inhibiting hypoxia-inducible factor-1, hypoxia-inducible factor-1α and 2α, and glucose transporter 1 as a prototypical downstream target of hypoxia-inducible factor-1α. Correlation analysis was done between these variables, and between factor inhibiting hypoxia-inducible factor-1...

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Authors: Shaida, N; Chan, P; Turley, H; Jones, C; Kanga, S

• Journal: Journal of urology
• Volume: 185
• Issue: 4
• Pages: 1513-1518
• Publication date: 2011-04-01
• DOI: 10.1016/j.juro.2010.12.001
• EISSN: 1527-3792
• ISSN: 0022-5347
• Language: English
• Keywords: Cell Nucleus; Prognosis; Mixed Function Oxygenases; Prostatic Neoplasms; Male; Repressor Proteins; Humans; Survival Rate