Journal article icon

Journal article

(-)-CHANA, a fluorogenic probe for detecting amyloid binding alcohol dehydrogenase HSD10 activity in living cells.

Abstract:

The association of 17β-hydroxysteroid dehydrogenase 10 (HSD10) with β-amyloid in the brain is known to contribute to the progression of Alzheimer's disease. Further, it has been shown that the interaction between the purified HSD10 and β-amyloid inhibits its enzymatic activity. However, to date no system has been developed to enable the study of HSD10 activity in intact living cells. To address this significant shortcoming, we have developed a novel fluorogenic probe, (-)-cyclohexenyl amino n...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/cb100199m

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Expand authors...
Journal:
ACS chemical biology
Volume:
5
Issue:
12
Pages:
1105-1114
Publication date:
2010-12-05
DOI:
EISSN:
1554-8937
ISSN:
1554-8929
URN:
uuid:ea14b54b-4886-44f4-92e5-9c0049c04ce2
Source identifiers:
90272
Local pid:
pubs:90272

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP