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Journal article

Diastereocontrolled synthesis of hydroxylated lactams

Abstract:
Highly diastereoselective reductions and organometallic additions in bicyclic lactams have been observed, which appear to result either from a stereoelectronic interaction of the pyramidalised nitrogen lone pair or from steric interactions in the bicyclic system. These products can be readily deprotected to give hydroxylated lactams.
Publication status:
Published

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Publisher copy:
10.1039/b108056n

Authors

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author


Journal:
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 More from this journal
Volume:
2
Issue:
1
Pages:
80-90
Publication date:
2002-01-01
DOI:
EISSN:
1364-5463
ISSN:
1472-7781


Language:
English
Pubs id:
pubs:38024
UUID:
uuid:ea036957-ab5f-42e6-b3c4-315d6b5e566a
Local pid:
pubs:38024
Source identifiers:
38024
Deposit date:
2012-12-19
ARK identifier:

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