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Journal article

Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS.

Abstract:

Clostridium difficile is a nosocomial bacterial pathogen causing antibiotic-associated diarrhea and fatal pseudomembranous colitis. Key virulence factors are toxin A and toxin B (TcdB), two highly related toxins that are members of the large clostridial toxin family. These large multifunctional proteins disrupt cell function using a glucosyltransferase domain that is translocated into the cytosol after vesicular internalization of intact holotoxin. Although substantial information about the b...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2010.01.012

Authors


Albesa-Jové, D More by this author
Bertrand, T More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
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Journal:
Journal of molecular biology
Volume:
396
Issue:
5
Pages:
1260-1270
Publication date:
2010-03-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:e9fb9392-0c51-45eb-8097-fa5f7a50627c
Source identifiers:
72796
Local pid:
pubs:72796

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