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A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

Abstract:

Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstream genes. We tested the idea that FTO itself is involved in obesity. We show that a dominant point mutation in the mouse Fto gene results in reduced fat mass, increased energy expenditure, and unchanged physic...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1000599

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Funding agency for:
Lee, S
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Funding agency for:
McTaggart, JS
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Funding agency for:
Deacon, R
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Funding agency for:
Gerken, T
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
5
Issue:
8
Pages:
Article: e1000599
Publication date:
2009-08-05
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:e9fb712a-c294-4e9c-869a-65fc5fac26ff
Source identifiers:
41439
Local pid:
pubs:41439

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