Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes: an analysis from the Collaborative Atorvastatin Diabetes Study (CARDS).

Journal article

BACKGROUND: We examined whether atorvastatin affects diabetic kidney disease and whether the effect of atorvastatin on cardiovascular disease (CVD) varies by kidney status in patients with diabetes. STUDY DESIGN: The Collaborative Atorvastatin Diabetes Study (CARDS) randomized placebo-controlled trial. SETTING and PARTICIPANTS: Patients with type 2 diabetes and no prior CVD (n = 2,838). INTERVENTION: Random allocation to atorvastatin, 10 mg/d, or placebo, with a median follow-up of 3.9 years...

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Authors: Colhoun, H; Betteridge, D; Durrington, P; Hitman, G; Neil, H

• Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation
• Volume: 54
• Issue: 5
• Pages: 810-819
• Publication date: 2009-11-01
• DOI: 10.1053/j.ajkd.2009.03.022
• EISSN: 1523-6838
• ISSN: 0272-6386
• Language: English
• Keywords: CARDS Investigators; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Female; Glomerular Filtration Rate; Cardiovascular Diseases; Middle Aged; Diabetes Mellitus, Type 2; Male; Albuminuria; Pyrroles; Diabetic Nephropathies; Aged; Humans; Heptanoic Acids