The anaphase promoting complex is required for memory function in mice.

Journal article

Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and learning behavior. One of the key pathways mediating protein degradation is proteosomal protein destruction. The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that targets proteins for proteosomal degradation by the 26S proteasome. While the...

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Authors: Kuczera, T; Stilling, R; Hsia, H; Bahari-Javan, S; Irniger, S

• Publication status: Published
• Journal: Learning and memory (Cold Spring Harbor, N.Y.)
• Volume: 18
• Issue: 1
• Pages: 49-57
• Publication date: 2011-01-01
• DOI: 10.1101/lm.1998411
• EISSN: 1549-5485
• ISSN: 1072-0502
• Language: English
• Keywords: Brain; Alzheimer Disease; Exploratory Behavior; Amyloid beta-Protein Precursor; Mice, Inbred C57BL; Learning Disorders; Maze Learning; Disease Models, Animal; Animals; Nerve Tissue Proteins; Conditioning, Classical; RNA, Messenger; Memory Disorders; Presenilin-1; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Mice; Humans; Fear; Ubiquitin-Protein Ligase Complexes; Memory; Analysis of Variance; Mice, Transgenic; Extinction, Psychological; Neurons