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Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Abstract:

To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide association studies (GWAS) of 3,393 cases and 12,462 controls. We used Gene Relationships Across Implicated Loci (GRAIL), a computational method that applies statistical text mining to PubMed abstracts, to score these 179 loci for functional relationships to genes in 16 established RA disease loci. We identified 22 ...

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Publication status:
Published

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Publisher copy:
10.1038/ng.479

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Journal:
Nature genetics
Volume:
41
Issue:
12
Pages:
1313-1318
Publication date:
2009-12-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:e9f2d827-de5f-4631-a941-3176ae43104d
Source identifiers:
108372
Local pid:
pubs:108372

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