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Glycoinositolphospholipid from Trypanosoma cruzi: structure, biosynthesis and immunobiology.

Abstract:

The pathogenic protozoan parasite Trypanosoma cruzi expresses on its surface an unusual family of glycoinositolphospholipids (GIPLs) closely related to glycosylphosphatidylinositol (GPI) anchors. Different parasite isolates express distinct GIPLs which fall into two series, depending on the substitution of the third mannosyl residue in the conserved glycan sequence Man4-(AEP)-GlcN-InsPO4 by ethanolamine phosphate or beta-galactofuranose. Although the exact role of these molecules in the cell ...

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Publication status:
Published

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Authors


Previato, JO More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
DosReis, GA More by this author
Todeschini, AR More by this author
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Journal:
Advances in parasitology
Volume:
56
Pages:
1-41
Publication date:
2004
DOI:
ISSN:
0065-308X
URN:
uuid:e9f01096-9258-45ed-8b26-e07f1343c296
Source identifiers:
230153
Local pid:
pubs:230153

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