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Glycoinositolphospholipid from Trypanosoma cruzi: structure, biosynthesis and immunobiology.

Abstract:

The pathogenic protozoan parasite Trypanosoma cruzi expresses on its surface an unusual family of glycoinositolphospholipids (GIPLs) closely related to glycosylphosphatidylinositol (GPI) anchors. Different parasite isolates express distinct GIPLs which fall into two series, depending on the substitution of the third mannosyl residue in the conserved glycan sequence Man4-(AEP)-GlcN-InsPO4 by ethanolamine phosphate or beta-galactofuranose. Although the exact role of these molecules in the cell ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Advances in parasitology
Volume:
56
Pages:
1-41
Publication date:
2004-01-01
DOI:
ISSN:
0065-308X
URN:
uuid:e9f01096-9258-45ed-8b26-e07f1343c296
Source identifiers:
230153
Local pid:
pubs:230153

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