Journal article icon

Journal article

Chemosensitivity profiles identify polymorphisms in the p53 network genes 14-3-3tau and CD44 that affect sarcoma incidence and survival.

Abstract:

The p53 regulatory network responds to cellular stresses by initiating processes such as cell cycle arrest and apoptosis. These responses inhibit cellular transformation and mediate the response to many forms of cancer therapies. Functional variants in the genes comprising this network could help identify individuals at greater risk for cancer and patients with poorer responses to therapies, but few such variants have been identified as yet. We use the NCI60 human tumor cell line anticancer d...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Cancer research
Volume:
70
Issue:
1
Pages:
172-180
Publication date:
2010-01-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:e9e958d5-1232-4664-97af-871a6d25eeaf
Source identifiers:
69622
Local pid:
pubs:69622

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP