Biaryl acids: novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2.

Journal article

A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC50S in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection. Synthesis of analogues to investigate the SAR is described. Two of these compounds have shown inhibition of HIV-2 RT only.

Authors: Milton, J; Slater, M; Bird, A; Spinks, D; Scott, G

• Publication status: Published
• Journal: Bioorganic and medicinal chemistry letters
• Volume: 8
• Issue: 19
• Pages: 2623-2628
• Publication date: 1998-10-01
• DOI: 10.1016/s0960-894x(98)00214-5
• EISSN: 1464-3405
• ISSN: 0960-894X
• Language: English
• Keywords: Carboxylic Acids; Anti-HIV Agents; Hydrocarbons, Aromatic; Structure-Activity Relationship; HIV Reverse Transcriptase; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase