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Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells.

Abstract:

Human respiratory syncytial virus (hRSV) is the leading cause of bronchiolitis and pneumonia in young children worldwide. The recurrent hRSV outbreaks and reinfections are the cause of a significant public health burden and associate with an inefficient antiviral immunity, even after disease resolution. Although several mouse- and human cell-based studies have shown that hRSV infection prevents naïve T-cell activation by antigen-presenting cells, the mechanism underlying such inhibition remai...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1400760111

Authors


Céspedes, PF More by this author
Ramírez, BA More by this author
Riquelme, SA More by this author
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Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
111
Issue:
31
Pages:
E3214-E3223
Publication date:
2014-08-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:e9dde145-77f0-4b2d-9ddf-c1588eb3451a
Source identifiers:
477772
Local pid:
pubs:477772

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