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Calcium and delayed potassium currents in mouse pancreatic beta-cells under voltage-clamp conditions.

Abstract:

Pancreatic islets of NMRI mice were dissociated into single cells which were kept in tissue culture for 1-3 days. The whole-cell configuration of the patch-clamp technique was used to study inward and delayed outward currents of beta-cells under voltage-clamp conditions at 20-22 degrees C. Outward currents were suppressed by substituting the impermeant cation N-methyl-D-glucamine for intracellular K+. The remaining inward current had a V-shaped current-voltage relation reaching a peak value o...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Role:
Author
Journal:
The Journal of physiology
Volume:
374
Pages:
531-550
Publication date:
1986-05-05
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:e9db6acd-02ab-44f1-a34c-348d39c0b8cc
Source identifiers:
26569
Local pid:
pubs:26569

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