HLA haplotype associations with disease.

Journal article

Abstract:: Interest recently has extended to the problem of looking for HLA haplotype associations with particular diseases. Higher order interactions, that is to say of particular haplotypes with a disease, are much more complicated than individual antigen associations, with which most disease studies have so far been concerned. Our aim in this work is to explain the concept of higher order interactions and to discuss the difficulties involved when trying to measure such haplotype associations. The mai...
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Role:

Author

Institution:

University of Oxford

Division:

MSD

Department:

RDM

Sub department:

Weatherall Insti. of Molecular Medicine

Role:

Author

Language:: English
Keywords:: Epitopes

Genetic Diseases, Inborn

Genotype

HLA Antigens

Alleles

Genetic Linkage

Humans

Gene Frequency

Models, Biological
Pubs id:: pubs:487544
UUID:: uuid:e9d6b0b1-b217-4ae3-8c38-054ddb64a210
Local pid:: pubs:487544
Source identifiers:: 487544
Deposit date:: 2014-10-29

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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