Serological identification of HL-A-linked human "Ia-type" antigens.

Journal article

By analogy with the mouse, human Ia antigens have been defined by mixed lymphocyte culture (MLC) inhibition and by serological tests on HL A identical unrelated individuals. The authors describe some new approaches to the ready identification of sera against Ia type antigens in man which make use of lymphoblastoid cell lines derived from B cells.

Authors: Jones, E; Goodfellow, P; Bodmer, J; Bodmer, W

• Publication status: Published
• Journal: Nature
• Volume: 256
• Issue: 5519
• Pages: 651-652
• Publication date: 1975-08-01
• DOI: 10.1038/256650a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Immunity; Cytotoxicity Tests, Immunologic; Isoantigens; HLA Antigens; beta 2-Microglobulin; Surface Properties; B-Lymphocytes; Cell Line; Chromosome Mapping; Fluorescent Antibody Technique; Histocompatibility Antigens; Cross Reactions; Humans; Genetic Linkage