- Abstract:
-
The transbilayer pore of the nicotinic acetylcholine receptor (nAChR) is formed by a pentameric bundle of M2 helices. Models of pentameric bundles of M2 helices have been generated using simulated annealing via restrained molecular dynamics. The influence of: (a) the initial C α template; and (b) screening of sidechain electrostatic interactions on the geometry of the resultant M2 helix bundles is explored. Parallel M2 helices, in the absence of sidechain electrostatic interactions, pack i...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 953.1KB)
-
- Publisher copy:
- 10.1016/0005-2736(95)00165-Y
-
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- Publisher:
- Elsevier Science B.V.
- Journal:
- Biochimica et Biophysica Acta (BBA) - Biomembranes Journal website
- Volume:
- 1239
- Issue:
- 2
- Pages:
- 122–132
- Publication date:
- 1995-11-05
- DOI:
- ISSN:
-
0006-291X
- URN:
-
uuid:e9b80e25-3f0e-4c54-a787-3fc16da85bab
- Local pid:
- ora:8091
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier Science B.V.
- Copyright date:
- 1995
- Notes:
- Copyright 1995 Elsevier B.V. All rights reserved. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://www.elsevier.com/open-access/userlicense/1.0/ (accessed 24/02/2014).
Journal article
Modelling packing interactions in parallel helix bundles: pentameric bundles of nicotinic receptor M2 helices
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