Journal article
Modelling packing interactions in parallel helix bundles: pentameric bundles of nicotinic receptor M2 helices
- Abstract:
-
The transbilayer pore of the nicotinic acetylcholine receptor (nAChR) is formed by a pentameric bundle of M2 helices. Models of pentameric bundles of M2 helices have been generated using simulated annealing via restrained molecular dynamics. The influence of: (a) the initial C α template; and (b) screening of sidechain electrostatic interactions on the geometry of the resultant M2 helix bundles is explored. Parallel M2 helices, in the absence of sidechain electrostatic interactions, pack i...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 953.1KB)
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- Publisher copy:
- 10.1016/0005-2736(95)00165-Y
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Biochimica et Biophysica Acta (BBA) - Biomembranes Journal website
- Volume:
- 1239
- Issue:
- 2
- Pages:
- 122–132
- Publication date:
- 1995-11-01
- DOI:
- ISSN:
-
0006-291X
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:e9b80e25-3f0e-4c54-a787-3fc16da85bab
- Local pid:
- ora:8091
- Deposit date:
- 2014-02-25
Related Items
Terms of use
- Copyright holder:
- Elsevier Science BV
- Copyright date:
- 1995
- Notes:
- Copyright 1995 Elsevier B.V. All rights reserved. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://www.elsevier.com/open-access/userlicense/1.0/ (accessed 24/02/2014).
- Licence:
- Other
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