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Electrospray ionisation-cleavable tandem nucleic acid mass tag-peptide nucleic acid conjugates: synthesis and applications to quantitative genomic analysis using electrospray ionisation-MS/MS.

Abstract:

The synthesis and characterization of isotopomer tandem nucleic acid mass tag-peptide nucleic acid (TNT-PNA) conjugates is described along with their use as electrospray ionisation-cleavable (ESI-Cleavable) hybridization probes for the detection and quantification of target DNA sequences by electrospray ionisation tandem mass spectrometry (ESI-MS/MS). ESI-cleavable peptide TNT isotopomers were introduced into PNA oligonucleotide sequences in a total synthesis approach. These conjugates were e...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkl1123

Authors


Thompson, A More by this author
Prescott, M More by this author
Chelebi, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Nucleic acids research
Volume:
35
Issue:
4
Pages:
e28
Publication date:
2007
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:e9b48f65-41bb-4b2a-aa40-ec61d245a4de
Source identifiers:
400031
Local pid:
pubs:400031

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